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Modulation of placental protein expression of lectin-like oxidised low density lipoprotein receptor-1 (LOX-1): implication in pregnancy-related disorders or pathologies

M Ethier-Chiasson, Sciences Biologiques, Universite du Quebec a Montreal, Montreal, Quebec, Canada
J Forest, Hopital St-Francois d'Assise, Universite Laval, Quebec, Quebec, Canada
Y Giguere, Hopital St-Francois d'Assise, Universite Laval, Quebec, Quebec, Canada
A Masse, Hopital St-Luc, Universite de Montreal, Montreal, Quebec, Canada
C Marseille-Tremblay, Sciences Biologiques, Universite du Quebec a Montreal, Montreal, Quebec, Canada
E Levy, Research Center, Ste-Justine Hospital, Montreal, Quebec, Canada
J Lafond, Sciences Biologiques, Universite du Quebec a Montreal, Montreal, Quebec, Canada

Correspondence: Julie Lafond, Email: lafond.julie{at}uqam.ca

Abstract

The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a newly described receptor for oxidatively modified low-density lipoprotein. The human pregnancy is associated with hyperlipidemia and oxidative stress. It has been reported that modification in maternal lipid profile can induce disturbance during pregnancy. In this study we have evaluated by Western-blot analysis the expression protein level of LOX-1 in human term placenta of women having plasma cholesterol level lower to 7mM or higher to 8mM and women of gestational diabetes mellitus. The present study demonstrates that the maternal lipid profile is associated with placental protein expression of LOX-1. A significant increase of the protein expression of LOX-1 was observed in placenta of women with elevated plasmatic total cholesterol level (>8 mM). In addition, the placental protein expression of LOX-1 is increased in mothers having the highest pre-pregnancy body mass index (BMI) and low (<7 mM) plasmatic total cholesterol level at term. Interestingly, the placental protein expression of LOX-1 is increased in presence of gestational diabetes mellitus pregnancies compared to normal lipids level pregnancies, without modification of mRNA expression. In conclusion, placental LOX-1 protein expression is associated with maternal lipid profile, pre-pregnancy BMI, and pathology of gestational diabetes mellitus.