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COMPARATIVE SERUM LEVELS OF AN ANTIFERTILITY OXAZOLIDINETHIONE (U-11634) IN RATS AND MONKEYS

5-(,,-Trifluoro-m-tolyloxymethyl)-2-oxazolidinethione, referred to as U-11634 (Youngdale, Duncan, Emmert & Lednicer, 1966), is orally active as an antifertility agent in the rat (Duncan, Johnston & Lyster, 1966) but not in the monkey (Meyer & Wolf, personal communication). This difference could reflect differences in drug availability following oral administration or could be due to the mechanism of action of U-11634. Species-specific responses have been reported for the antifertility diphenylindenes (Duncan, Stucki, Lyster & Lednicer, 1962; Duncan & Lyster, 1962) and diphenyldihydronaphthalenes (Duncan, Lyster, Clark & Lednicer, 1963). Accordingly, a comparison of drug availability based on serum drug levels has been made following oral administration of U-11634 to the rat and monkey.

Eight groups of five female Sprague-Dawley rats, each weighing 219 to 231 g, were employed. One group served as a control. Each member of the other